How Genetic Screening Has Impacted The Process of IVF
It may come as a surprise to many that technology in today’s world, concerning treatments for IVF patients, has advanced at a level that doctors, all over the world, now have methods to produce a genetically healthy baby.
Chromosomes are DNA and protein structures that contain information about our genetics. An ideal human embryo has 23 sets of chromosomes. However, abnormalities that occur in the early stage of sperm or egg’s development may lead to a variation in the count of chromosomes in the embryo. These abnormalities in chromosomes are termed as aneuploidies.
Chromosomal abnormalities can affect women of all ages and are responsible for miscarriages in the first trimester. Doctors explain that the chances of abnormalities in the chromosomes increase with the maternal age and have also been a cause of infertility in women. Most chromosomal anomalies result in miscarriages while others are associated with genetic disorders.
What is PGT-A?
Preimplantation Genetic Testing for Aneuploidy is a test conducted to determine the genetic anomalies that could be caused by screening the 23 sets of chromosomes to ensure a healthy embryo implantation free of all genetic anomalies.
By carefully selecting and preparing the correct number and type of chromosomes, the baby will grow up to be healthier. PGT-A test can identify the healthy chromosomes that will result in a successful implantation as well as a healthy live birth.
After the selection and assembling of the accurate number of chromosomes, it is transferred to the uterus.
Preimplantation Genetic Testing for Aneuploidy:
- Improves the chances of successful IVF
- Reduces the risk of miscarriage
- Reduces the chances and complications leading to multiple pregnancies
- Prevents the presence of a genetic disorder in the baby
Who Can Benefit From PGT-A?
PGT-A has proved to be beneficial for couples who are seeking treatments for infertility as well as for the ones who have suffered miscarriages or have genetic diseases. Almost all pregnancies are at a risk of chromosome abnormality. However, about 50% of the embryos in an IVF cycle are aneuploid.
Aneuploidies are a significant reason for failed pregnancies or infertility among couples. Several practitioners have stated that a woman’s quality of eggs, when she reaches a certain age, starts to decline which puts the embryo at a risk of contracting chromosomal abnormalities. A woman’s age is an integral factor affecting the success of the pregnancy.
This screening would improve the odds of successful IVF results, leading to successful pregnancy in infertile couples. However, it is a preferable treatment for couples who have had recurrent miscarriages, previously failed IVF attempts, women of age over 35 or couples with a history of genetic disorders in their families.